Select the statement that is true about bilirubin metabolism

A: Indirect bilirubin is formed in the liver by addition of two sugar
B: Macrophages of the spleen liberate bilirubin during Hb catabolism
C: Urobilinogen is not water soluble and is not excreted in urine
D: Normally，the major fraction of bilirubin in the blood is the direct（conjugated）form released from macrophages
E: The small amount of indirect bilirubin in the plasma can been absorbed from the intestine by the portal circulation

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