A 32-year-old man with typical early diastolic murmur in the 3rd left intercostal space is thought to have aortic insufficiency，which should be differentiated from early blowing diastolic murmur（Graham Stell murmur）in pulmonary valve insufficiency.Which in the following supports the former diagnosis?
A: murmur is loudest in the second left intercostal space
B: left ventricular enlargement
C: murmur is more obvious at the end of inspiration
D: no change in blood pressure
E: often accompanied with increased first heart sound