A 38-year-old women complains of fatigue,loss of appetite,jaundice for past 6 month.Laboratory studies are significant for atotal bilirubin(82μmol/L)with a direct fraction of 35(μmol/L,alanine aminotransferase(ALT)of 232IU/L,aspartate aminotrasferase(AST)of 126IU/L,both HBV and HCV are negative. Serum ANA 1：320 positive,SMA 1：160 positive,AMA-M2 1：160 positive.Abdominal ultrasound type B shows mild hepatomegaly.Which of the following disease is most likely diagnosis