Under the light microscopy, the major pathologic change in IgA nephropathy

A: minor glomerular abnormalities
B: mesangial proliferative glomerulonephritis
C: focal proliferative glomerulonephritis
D: endocapillary proliferative glomerulonephritis
E: mesangiocapillary glomerulonephritis

答案：

解析：

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female，64 years， she was admitted into hospital with the chief complain of repeat right upper abdominal pain for 12 years. The pain was not severe but radiated to the right shoulder. No jaundice， no fever. No acid regurgitation， no hiccups or belching. It usually went away without any treatments. In the recent 5 months，the pain became persistence. Moreover，she felt fatigue and lost of the body weight. PE： right upper quadrant abdominal tenderness. 4cm×4cm mass can be palpable just under the right costal margin. Blood routine test： HB 8.6g /L B-ultrasound exam showed： enlarged gallbladder with obvious thickened wall. Intra-hepatic duct slightly enlarged. The most possible diagnosis of this case is：